Comparative analysis of efficacy of lignocaine 1.5 mg/kg and two different doses of
dexmedetomidine (0.5 μg/kg and 1 μg/kg) inattenuating the hemodynamic pressure response to laryngosdopy and intubation.

context:Laryngoscopy and intubation cause an intense reflex increase in heart rate,blood pressure due to an increased synpathoadrenal pressor response lignoocaine has shown blunting of pressor response to intubation.Dexmedetomidine has sympatholytic effects.

Aims:To the best of our knowledge there is no study comparing the efficacy of lignocaine with two different doses of dexmedetomidine for attenuating the pressor response. With this idea, we planned to conduct the present study.

Materials and Methods:After approval by the Hospital Ethics committee, 90 consenting adultsaged 18-65 years of age of either sex of non-hypertensive ASA Grade I or II were randomly allocated into three groups.Group D1- IV Dexmedetomidine 0.5μg/kg over 10 minutes Group D2- IV Dexmedetomidine 1µg/kg over 10 minutes Group X- IV Lignocaine 1.5mg/kg in 10 ml normal saline

Results:Dexmedetomidine 1µg/kg was more effective than 0.5µg/kg and lignocaine 1.5mg/kg in attenuating the pressor response.

Conclusions:We conclude that dexmedetomidine 1µg/kg adequately attenuates the hemodynamic response to laryngoscopy and endotracheal intubation when compared with dexmedetomidine 0.5µg/kg and lignocaine 1.5mg/kg.

full text download